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| Year : 1997 | Volume
: 2
| Issue : 4 | Page : 130-135 |
Fungal infections as a xause of morbidity and morality in posterior urethral valves.
R Lal, TK Lama, V Bhatnagar, S Agarwala, U Banerjee, U Bajpai, DK Gupta, DK Mitra
Department of Pediatric Surgery & Microbiology, All Institute of Medical Sciences, New Delhi-110029, India
Correspondence Address:
R Lal
Department of Pediatric Surgery & Microbiology, All Institute of Medical Sciences, New Delhi-110029
India
 Source of Support: None, Conflict of Interest: None  | Check |
ABSTRACT: This retrospective clinical study highlights the importance of fungal infections as cause of morbidity and mortality in children with posterior urethral valves treated at a tertiary care centre. The incidence of proven fungal infection of the urinary tract was 15.5 percent and fungal sepsis contributed to mortality in 53 percent patients of all the valve patients who died during the first hospital admission over a 4-year period. The patient group which was at the highest risk of developing fungal infection consisted of newborns and infants with deranged renal function and obstructed urinary tracts who were subjected to prolonged hospital care and indwelling catheters and multiple broad-spectrum antibiotics. Persistent non-specific clinical features of sepsis, despite antibiotics, associated mucocutaneous candidiasis and an unhealthy looking urinary stoma in a predisposed baby were used as indications for screening for fungal infection. Fluconazole was found to be an effective, well tolerated and convenient antifungal therapy. The message for a clinician from this clinical study is to keep a high index of suspicion and to treat expeditiously in the presence of substantial clinical evidence and a positive screening test.
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