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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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Year : 1998  |  Volume : 3  |  Issue : 4  |  Page : 96-102

Effect of oral zinc supplementation on mural fibrosis in esophageal alkali burns in rats.

Department of Pediatric Surgery, AIIMS, New DElhi-110029

Correspondence Address:
K Das
Department of Pediatric Surgery, AIIMS, New DElhi-110029

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Source of Support: None, Conflict of Interest: None

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ABSTRACT: Esophageal stricture in children is commonly due to accidental ingestion of strong corrosives. Prevention of esophageal fibrosis is crucial to limit its vicious sequel. Hitherto discovered inhibitors of collagen synthesis (eg. steroids, penicillamine, etc) have shown equivocal results in clinical studies. Zine inhibits prolyl/lysyl hydroxylase key enzymes in collagen synthesis. The effect of oral zine supplementation in rats subjected to a 'standard esophageal alkali burn' was evaluated with suitable controls. Double Blind evaluation of the resultant submucosal fibrosis histologically with connective tissue stains and semiquantitative estimation by a computerized image analysis system was performed. Zine supplemented drinking water (227 mg/L of Zn plus) significantly decreased submucosal fibrosis in alkali induced esophageal stricture in rats.

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  2005 - Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer - Medknow 

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