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| Year : 1999 | Volume
: 4
| Issue : 2 | Page : 81-83 |
Indocyanine green clearance test to evaluate the status of liver functions in extrahepatic biliary obstruction in rats.
H Dutta, DN Rao, DK Gupta
Department of Pediatric Surgery and Biochemistry, All Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India
Correspondence Address:
H Dutta
Department of Pediatric Surgery and Biochemistry, All Institute of Medical Sciences, Ansari Nagar, New Delhi-110029
India
 Source of Support: None, Conflict of Interest: None  | Check |
ABSTRACT: An experimental model of extrahepatic billary obstruction was created by injecting OK-432 into bile ducts of albine rats. Indocyanin Green (ICG) which is a tricarboxylic acid compound, is taken up and excreted solely by the hepatocytes, was used to assess the hepatocyte function. The ICG was injected intravenously at 3 and 6 weeks following OK-432 injection. Serial arterial blood samples were collected and fractional clearance (K-valu) of ICG was calculated. Study revealed that K-value of ICG is a sensitive marker of hepatocyte function,
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