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| Year : 2002 | Volume
: 7
| Issue : 3 | Page : 130-133 |
Histopathological examination in the study of idiopathic hypertrophic pyloric stenosis
AV Apte, A Dhulkotia, AN Gangopadhyay, NC Aryya
Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University Varanasi 221 005, India
Correspondence Address:
AV Apte
Department of Pediatric Surgery, Institute of Medical Sciences, Banaras Hindu University Varanasi 221 005
India
 Source of Support: None, Conflict of Interest: None  | Check |
ABSTRACT: There are many hypotheses for the etopathogenesis of infantile hypertrophic pyloric stenosis (IHPS), as no definitive specific etiological factor has been identified till date. Our work is an attempt further, to understand the histopathology involved in IHPS. Biopsy specimens were obtained from 20 cases IHPS at pyloromyotomy by taking full thickness of pyloric muscles; these were studied for histological details by using different staining techniques. Hematoxylin and eosin stained paraffin sections were employed for evaluation of 20 biopsy specimens. Histologically IHPS cases showed smooth muscle cells running in different directions in all cases with leiomyomatous appearance in 20 percent cases. Muscular hypertrophy was appreciated in 60 percent cases and 10 percent showed nerve tissue undergoing degeneration. Ganglion cells were present in 20 percent cases and 35 percent cases had varying degree of increase in connective tissue stroma. Mild focal inflammatory cells were noticed in muscle tissues. The above findings have also been documented by Que & Puri, although in our study, the findings indicated by those authors were not found in all cases for running smooth muscle cells in all directions and presence of nerve bundles. The presence of degenerative changes in nerves and ganglion cells may indicate their possible role in etopathogenesis of IHPS.
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