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| Year : 2003 | Volume
: 8
| Issue : 4 | Page : 195-201 |
Optometry of nerve trunks in Hirschsprung's disease.
R Bandyopadhyay, U Chatterjee, AK Basu, S Banerjee
4, Gorky Terrace, Kolkata 700017
Correspondence Address:
R Bandyopadhyay
4, Gorky Terrace, Kolkata 700017
 Source of Support: None, Conflict of Interest: None  | Check |
ABSTRACT: It is well accepted that increased nerve trunk density and thickness are common in aganglionic segments of colon in Hirschsprung's disease (HD). Attempts have been made previously to quantitate the degree of increase in density as well as thickness of nerves. In this study, 36 cases of defective intestinal innervation were analysed, 30 of which were HD. Sections of ganglionic and aganglionic colon were taken and a detailed histological analysis was performed. Nerve trunk were studied in terms of density and thickness. It was found that nerve trunks were more numerous in the aganglionic portion and also thicker compared to those in the ganglionic colon. Average number of nerve trunks in ganglionic and aganglionic colon were 27.50/10 mm2 and 70.28/10 mm2 respectively. Nerve trunks thicker than 45mu was found helpful in the diagnosis of HD when used as additional positive objective criteria apart from absence of ganglion cells. Histopathological study of suspected cases of HD is important as it serves to distinguish cases of HD from those of neuronal intestinal dysplasia (NID) thus helping in selecting the therapeutic approach.
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