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IMAGES IN CLINICAL PRACTICE |
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| Year : 2021 | Volume
: 26
| Issue : 1 | Page : 63-64 |
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Multiple Cutaneous Malignancies in a Child with Xeroderma Pigmentosa
Padmapriya Balakrishnan1, Thirunavukkarasu Arun Babu2
1 Indira Gandhi Medical College and Research Institute, Puducherry, India
2 Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, India
| Date of Submission | 07-Apr-2020 |
| Date of Decision | 13-Aug-2020 |
| Date of Acceptance | 22-Sep-2020 |
| Date of Web Publication | 11-Jan-2021 |
Correspondence Address:
Dr. Thirunavukkarasu Arun Babu
Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jiaps.JIAPS_97_20
How to cite this article:
Balakrishnan P, Babu TA. Multiple Cutaneous Malignancies in a Child with Xeroderma Pigmentosa. J Indian Assoc Pediatr Surg 2021;26:63-4 |
How to cite this URL:
Balakrishnan P, Babu TA. Multiple Cutaneous Malignancies in a Child with Xeroderma Pigmentosa. J Indian Assoc Pediatr Surg [serial online] 2021 [cited 2023 Mar 30];26:63-4. Available from: https://www.jiaps.com/text.asp?2021/26/1/63/306710 |
A 11-year-old boy with xeroderma pigmentosa (XP) presented with multiple ulcerated nodules in the right cheek, dorsum of the nose, forehead, right ear lobe and ulceroproliferative like growth over the left nasolabial fold [Figure 1]a and ulceroproliferative nodule over the right leg [Figure 1]b. Histopathology sections from skin lesions confirmed the simultaneous occurrence of three cutaneous malignancies, namely squamous cell carcinoma, basal cell carcinoma, and malignant melanoma [Figure 2]a,[Figure 2]b,[Figure 2]c. | Figure 1: (a) Multiple ulcerated nodules in the right cheek, dorsum of nose, forehead, right ear lobe, and ulceroproliferative like growth over the left nasolabial fold. (b) Ulceroproliferative nodule over the right leg
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 | Figure 2: (a) Sections from nodules over the right cheek and dorsum of nose showed features of basal cell carcinoma. (b) Sections from ulceroproliferative growth over the left cheek showed invasive islands of pleomorphic squamous epithelial cells with keratin pearls infiltrating the underlying stroma with focal collections of lymphocytes. (c) Sections from ulceroproliferative growth over the right leg showed surface stratified squamous keratinized epithelium with invasive islands of polygonal tumor cells with prominent nucleoli and intracellular melanin pigment. (H and E, ×400)
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XP is a rare genetically inherited disorder associated with oculocutaneous premalignant and malignant lesions and progressive neurodegeneration predominantly occurring during childhood and adolescence.[1] It is an autosomal recessive disorder caused by the impaired repair mechanism of ultraviolet-B rays-induced DNA damage to skin and eyes.[2] The main cutaneous clinical features include photosensitivity, pigmentary changes, premature skin aging, actinic keratosis, and development of multiple cutaneous malignancies, more commonly basal cell carcinoma, squamous cell carcinoma, malignant melanoma, and fibrosarcoma.[1],[2]
Declaration of patient consent
The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.
Financial support and sponsorship
Nil.
Conflicts of interest
There are no conflicts of interest.
 References | |  |
| 1. | Shankar R, Qureshi SS, Sugoor P, Kembhavi S, Yadav PS, Mukta R. Colossal squamous cell carcinoma of the face in a child with xeroderma pigmentosum. J Indian Assoc Pediatr Surg 2014;19:185-6.  [ PUBMED] [Full text] |
| 2. | Singh AP, Ansari M, Shukla AK. Basal cell carcinoma with xeroderma pigmentosum in an 8-year-old girl. J Indian Assoc Pediatr Surg 2019;24:314-6. [ PUBMED] [Full text] |
[Figure 1], [Figure 2]
| This article has been cited by | | 1 |
Pigmented xeroderma: literature review and clinical case |
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| Igor A. Gorlanov, Olga K. Mineeva, Sergei A. Laptiev, Larisa M. Leina, Irina R. Milyavskaya, Elena P. Fedotova, Elena S. Bolshakova | | Pediatrician (St. Petersburg). 2022; 13(5): 129 | | [Pubmed] | [DOI] | |
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