| ORIGINAL ARTICLE
|Year : 2021 | Volume
| Issue : 5 | Page : 327-333
Clinicopathological study of primary pediatric gastrointestinal lymphomas
Moupali Ghosh1, Moumita Sengupta1, Shibsankar Barman2, Uttara Chatterjee1, Madhumita Mukhopadhyay1, Ruchirendu Sarkar2, Koushik Saha3, Ashoke Kumar Basu4
1 Department of Pathology, IPGME&R, Kolkata, West Bengal, India
2 Department of Pediatric Surgery, IPGME&R, Kolkata, West Bengal, India
3 Department of Pediatric Surgery, NRS Medical College, Kolkata, West Bengal, India
4 Department of Pediatric Surgery, Institute of Child Health, Kolkata, West Bengal, India
Background: Primary gastrointestinal lymphomas (PGIL) are uncommon in children and account for <5% of all pediatric malignancies. The objective of our study was to analyze the prognostic factors of pediatric PGILs with reference to its histological subtypes, stage, and outcomes using immunohistochemistry.
Materials and Methods: Twenty cases were studied over 11 years. Clinicopathological profiles, histological details, and immunohistochemical (IHC) profiles were analyzed.
Results: The mean age at the presentation was 6 years. Using IHC stains (CD CD10, CD19, CD20, CD3, terminal deoxynucleotidyl transferase, BCL 2 and 6, PAX 5, and MUM1), diffuse large B-cell lymphoma (DLBCL) was most prevalent (45%), followed by Burkitt lymphoma (35%) and lymphoblastic lymphoma (20%). DLBCLs (9) were classified using the Han's algorithm. Six were activated B-cell and 3 were germinal center B-cell subtypes. The cases of lymphoblastic lymphoma and those in Stage I disease had the best prognosis.
Conclusion: Pediatric PGILs have variable presentation, outcomes, and diverse treatment modalities depending on the histological subtypes. A panel of IHC stains can be a useful adjunct for the categorization and prognosis of pediatric PGILs.
Dr. Uttara Chatterjee
Department of Pathology, IPGME&R, Kolkata, West Bengal
Source of Support: None, Conflict of Interest: None
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