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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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LETTERS TO THE EDITOR
Year : 2021  |  Volume : 26  |  Issue : 6  |  Page : 466
 

Impact of SARS-CoV-2 on acute appendicitis in children: A retrospective study


1 Department of General Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India
2 Department of Paediatric Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India

Date of Submission30-Mar-2021
Date of Decision04-Jun-2021
Date of Acceptance17-Jul-2021
Date of Web Publication12-Nov-2021

Correspondence Address:
Dr. Debashri Shankarraman
Department of General Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai - 600 116, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jiaps.JIAPS_49_21

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How to cite this article:
Shankarraman D, Pondugula N, Agarwal P, Madhu R, Sundaram J, Bharathi S. Impact of SARS-CoV-2 on acute appendicitis in children: A retrospective study. J Indian Assoc Pediatr Surg 2021;26:466

How to cite this URL:
Shankarraman D, Pondugula N, Agarwal P, Madhu R, Sundaram J, Bharathi S. Impact of SARS-CoV-2 on acute appendicitis in children: A retrospective study. J Indian Assoc Pediatr Surg [serial online] 2021 [cited 2021 Dec 4];26:466. Available from: https://www.jiaps.com/text.asp?2021/26/6/466/330381




Acute appendicitis is one of the most common surgical emergencies encountered in children. In our institute, we carried out a study to identify if there is a direct pathological correlation between SARS CoV-2 virus and complicated acute appendicitis. A retrospective study was carried out comparing data of patients with acute appendicitis Pre-COVID and During-COVID. Analysis revealed a higher incidence of complications such as perforation, gangrene and abscess formation during COVID pandemic and the duration of symptoms between both groups was statistically insignificant.4 patients had tested positive for anti-COVID antibodies. This suggests Multi-system inflammatory syndrome in Children [MIS-C] related to SARS-CoV-2 Virus possibly contributed to complications. This is explained by a)the appendix being one of the targets of the virus due to expression of ACE2 receptors on glandular cells, b)children with MIS-C more often test positive for antibody to SARS-CoV-2 than nasopharyngeal RT-PCR assay. We advocate the use of stool-RT PCR for COVID-19 to confirm the pathological role of COVID-19 on acute appendicitis [Table 1].[1],[2]
Table 1: Comparison of Data of both groups

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Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
   References Top

1.
Orthopoulos G, Santone E, Izzo F, Tirabassi M, Pérez-Caraballo AM, Corriveau N, et al. Increasing incidence of complicated appendicitis during COVID-19 pandemic. Am J Surg [Internet]. 2020; Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521886/. [Last cited on 2020 Dec 1].  Back to cited text no. 1
    
2.
CDC. Multisystem Inflammatory Syndrome in Children (MIS-C) [Internet]. Centers for Disease Control and Prevention. 2020. Available from: https://www.cdc.gov/mis-c/cases/index.html. [Last cited on 2021 Jan 31].  Back to cited text no. 2
    



 
 
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