| ORIGINAL ARTICLE
|Year : 2022 | Volume
| Issue : 3 | Page : 304-308
Pediatric colorectal carcinoma: A series of seven cases
Nidhi Mahajan1, Harshita Agarwal1, Chhabi Ranu Gupta2, Mamta Sengar2, Arti Khatri1, Niyaz Khan2
1 Department of Pathology, Chacha Nehru Bal Chiktsalaya, Delhi, India
2 Department of Pediatric Surgery, Chacha Nehru Bal Chiktsalaya, Delhi, India
Introduction: Colorectal carcinoma (CRC) accounts for <1% of all the neoplasms of children. Unfavorable histology and delayed diagnosis often result in poor outcome. This study aimed to investigate the clinical characteristic and prognosis of pediatric patients with CRC.
Materials and Methods: A retrospective review of medical records of all patients diagnosed of CRC between 2015 and 2020 was performed. Data regarding gender, age, location, and histopathology were collected.
Results: Seven children (5 males and 2 females) were included in the study. Age ranged between 8.6 and 11.8 years. Abdominal pain was the most common symptom. The duration between onset of symptoms to the diagnosis ranged from 5 days to 8 months. Right-sided tumors were more common than the left side. Histopathological examination showed mucinous adenocarcinoma in four/seven patients and signet cell variant was seen in 2/7. Immunohistochemistry was positive for cytokeratin and beta-catenin, however, all microsatellite instability markers were found negative. Despite surgical treatment and chemotherapy, four of our cases faced mortality and one patient was lost to follow-up.
Conclusion: CRC can present in first decade of life and often misdiagnosed. Pediatric CRC has distinct tumor biology and shares a poor prognosis. Paucity of literature from the Indian subcontinent should urge further clinicopathological trials for establishing etiology and for refining treatment recommendations in these children.
Dr. Niyaz Khan
Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi - 110 031
Source of Support: None, Conflict of Interest: None
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