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Journal of Indian Association of Pediatric Surgeons
     Journal of Indian Association of Pediatric Surgeons
Official journal of the Indian Association of Pediatric Surgeons         
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   2015| October-December  | Volume 20 | Issue 4  
    Online since September 2, 2015

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Free radicals and antioxidants status in neonates with congenital malformation
Bedabrata Mukhopadhyay, Ajay Narayan Gongopadhyay, Anjali Rani, Roshni Gavel, Surendra Pratap Mishra
October-December 2015, 20(4):179-183
DOI:10.4103/0971-9261.161037  PMID:26628809
Background: Several studies using animal models have shown that oxidative stress during pregnancy may play an important role in causing birth defects. Congenital anomalies affect an estimated 270,000 newborns who die during the first 28 days of life every year from different birth defects. Hence, at present many research works are going on to reduce the infant mortality from congenital anomaly. [1] Objective: The objective was to measure the oxidant and antioxidant level in the serum of newborn babies with the congenital anomaly and compare these levels with age and sex matched normal neonates. This is to identify any role of oxidative stress in the causation of congenital anomaly. Materials and Methods: This case-control study included 159 participants: 106 newborns with the congenital anomaly and 53 healthy newborns. The markers of oxidative stress like serum malondialdehyde (MDA) level, protein carbonyl (PC) level, and the activity of antioxidants such as Vitamin C, glutathione were measured in both cases (neonates with congenital anomaly) and controls (normal healthy neonates). These parameters were statistically compared. Results: MDA levels and PC levels were significantly higher (P < 0.0001), and Vitamin C and reduced glutathione levels were significantly lower (P < 0.0001), in newborns with congenital malformation than in healthy newborns. Conclusions: Increased lipid peroxidation and protein carbonylation might play an important role in the pathogenesis of congenital anomaly. Impairment of the free radical/antioxidant balance is leading to increased free radical damage in neonates with congenital malformation.
  7 4,233 124
Non-rhabdomyosarcoma soft-tissue sarcomas in children: Contemporary appraisal and experience from a single centre
Sajid S Qureshi, Monica Bhagat
October-December 2015, 20(4):165-169
DOI:10.4103/0971-9261.154664  PMID:26628806
Nonrhabdmyosarcoma soft tissue sarcomas (NRSTS) include a cluster of different types of soft tissue sarcomas clubbed together due to the rarity of individual subtypes. The diagnostic accuracy is lately reinforced due to the availability of immunohistochemical and molecular markers. Surgery is the central modality of treatment since many of them are insensitive to chemotherapy. With the availability of rational risk stratification system, efforts are in progress to evaluate the role of neoadjuvant chemotherapy and radiotherapy to improve outcomes especially for the locally advanced disease. The survival remains dismal for metastatic disease. This review highlights the current status of NRSTS and also describes the experience from a single centre in treatment of NRSTS.
  6 5,491 223
Enteric duplication in children: Experience from a tertiary center in South India
Susan Jehangir, Pradeep Joseph Ninan, Tarun John Jacob, Anu Eapen, John Mathai, Reju Joseph Thomas, Sampath Karl
October-December 2015, 20(4):174-178
DOI:10.4103/0971-9261.164246  PMID:26628808
Background: Enteric duplications (EDs) are rare aberrations of the embryonic gut. This study was undertaken to define the clinical characteristics and management challenges of this unusual entity in the Indian population. Materials and Methods: Hospital records of 35 children with 38 ED operated between 2003 and 2014 were analyzed and followed up. Results: The median age at presentation was 285 days (range 1-day to 16 years) with male preponderance (71%). Small bowel duplications were the most common (44%), and thoracoabdominal duplications were seen in 8% children compared to 2% in the literature. The median duration of symptoms was 18 days (interquartile range [IQR] 3-210 days). Associated anomalies were seen in 49% children with vertebral and spinal anomalies being the most common. Ultrasonogram (US) was done in 83% children and had a sensitivity of 55%. In the presence of a gastrointestinal bleed, Technetium 99m pertechnetate scintigraphy scan had a positive predictive value of 80%. Thirty-five lesions were completely removed. Mucosectomy was done in two children, and one total colonic duplication was left in situ after providing adequate internal drainage. There was no postoperative mortality. The follow-up was possible in 66% children. Conclusions: EDs are uncommon and have varied, nonspecific symptoms. Thoracoabdominal duplications are more common in the Indian population. The US is a good screening tool but requires a high index of suspicion where complete excision is not possible; the provision of adequate internal drainage is an acceptable alternative. The long-term prognosis of children with ED depends on the extent of physiological disturbance due to associated anomalies.
  4 4,234 173
Robotic excision of paraesophageal bronchogenic cyst in a 9-year-old child
Belal Bin Asaf, Arvind Kumar, CL Vijay
October-December 2015, 20(4):191-193
DOI:10.4103/0971-9261.164256  PMID:26628812
Bronchogenic cysts are often asymptomatic and discovered as an incidental finding. They may become symptomatic due to esophageal compression as they increase in size or from development of infection. We report a case of a 9-year-old male with an asymptomatic bronchogenic cyst who underwent successful robotic assisted thoracoscopic excision.
  2 3,724 97
Correlation of pre- and post-operative liver function, duct diameter at porta hepatis, and portal fibrosis with surgical outcomes in biliary atresia
Rajib Ray Baruah, Veereshwar Bhatnagar, Sandeep Agarwala, Siddhartha Datta Gupta
October-December 2015, 20(4):184-188
DOI:10.4103/0971-9261.161040  PMID:26628810
Background and Aims: Extrahepatic biliary atresia is one of the most challenging conditions in pediatric surgery. The definition of prognostic factors is controversial. Surgical outcomes after bilioenteric drainage procedures are variable. This study attempts to correlate the pre- and post-operative liver histology with clinical factors in order to define early predictors of success. Materials and Methods: Twenty consecutive patients, treated by Kasai's portoenterostomy (KP) over a 3 years period were included in this study. Tissue obtained from the porta hepatis was analyzed for duct size using an optical micrometer and was categorized into three types: I-No demonstrable ducts; II - <50 μ; III - >50 μ. Pre- and post-operative liver biopsy was analyzed for architectural changes and fibrosis; hepatic fibrosis was quantified using existing criteria. Pre- and post-operative liver function tests (LFTs) were also done. Surgical outcomes were defined as: (A) Disappearance of jaundice within 3 months; (B) initial disappearance of jaundice with recurrence by 6 months and (C) persistence of jaundice. Duct diameters, fibrosis score, and LFT were correlated with age and clinical outcomes. Results: The surgical outcomes were: A-6 patients (30%), B-6 patients (30%), C-8 patients (40%). The duct size at the porta was I-3 patients, II-11 patients, and III-4 patients (tissue was not available in 2 cases). The change in total serum bilirubin (mg%) from pre- to post-operative period was 13.6 ± 3.9 (Group A), 4.6 ± 2.8 (Group B), and 3.4 ± 3.9 (group C) (P < 0.001) and direct and indirect fractions followed a similar trend; the changes in liver enzymes were not significant. The changes in hepatic histopathological changes (ballooning of hepatocytes, giant cells, cholestasis, portal tract infiltration, ductular proliferation, lobular necrosis, and fibrosis) were also not significant but there was a definite trend in the change in fibrosis -1.500 ± 1.643 (Group A), 0.667 ± 2.582 (Group B), and 1.500 ± 1.852 (Group C) - reduction of fibrosis with good results and progression of fibrosis with poor results. Conclusions: Following KP, jaundice persisted in 40% patients; it disappeared in 60% patients but reappeared in half of these patients 6 months postoperatively. The duct size at the porta hepatis did not correlate with age or surgical outcome. Serum bilirubin showed the best correlation with surgical outcome. Postoperative changes in hepatic fibrosis seem to have some bearing on surgical outcomes-progressive fibrosis is a poor prognostic factor.
  2 4,284 150
Intermuscular lipoma in a 4-year-old child presenting like Spigelian hernia
Manoj Saha
October-December 2015, 20(4):189-190
DOI:10.4103/0971-9261.154643  PMID:26628811
Lipomas are commonest benign tumor and can occur at any part of the body, but intermuscular lipomas are very rare and usually occur at middle age or later. Intermuscular lipomas remain hidden till they attain a large size. They commonly appear on anterior abdominal wall. We treated a case of intermuscular lipoma in a 4-year-old girl. It presented as a bulge at right iliac fossa during straining; its location and symptoms were similar to that of Spigelian hernia. Actual diagnosis was made under general anesthesia and complete surgical excision was done. This is a rare mode of presentation of an intermuscular lipoma. Intermuscular lipoma of the abdominal wall at this young age was not reported earlier.
  1 4,294 105
Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon in a neonate of life- and limb-threatening nature: A case report
Anoop Subash, Ganesh K Senthil, Ramkumar Ramamoorthy, Andal Appasamy, Namasivayam Selvarajan
October-December 2015, 20(4):194-196
DOI:10.4103/0971-9261.154671  PMID:26628813
Kaposiform hemangioendothelioma involving whole of a leg in a neonate with Kasabach-Merritt phenomenon causing limb and life-threatening situation has not been reported. One such case and its successful management is presented in this case report. Literature review is made.
  1 4,396 95
A new, simple operative approach for bilateral inguinal hernia repair in girls: A single transverse supra-pubic incision
Abdalla E Zarroug, Antar M Alkhebel, Waleed O Gibreel, Mohammed Almassry
October-December 2015, 20(4):170-173
DOI:10.4103/0971-9261.154649  PMID:26628807
Background: Inguinal hernia repair remains one of the most common operations performed by pediatric surgeons. We described a new surgical approach for treating bilateral inguinal hernias in girls through a small single transverse supra-pubic incision. Materials and Methods: A new approach was performed on female children 12-years-old and younger with bilateral inguinal hernias between January 2005 and April 2012. Technique: A single transverse suprapubic incision (1-1.5 cm) was made. Using sharp and blunt dissection bilateral hernias were exposed and repaired using a standard high ligation. Results: Ninety-nine girls with a preoperative clinical diagnosis of bilateral inguinal hernia were included. Median age was 2 years (range: 1 month to 12 years). All patients underwent general anesthesia. Median operative time was 12 minutes (range 5-22). There were no intra-operative complications or misdiagnosis. Two patients had bilateral sliding hernias and the remainder had indirect hernias. Post-operatively two patients developed non-expanding small hematomas, both treated non-operatively without sequelae. There were zero hernia recurrence and median follow-up was 5 years (range: 1-8 years) on 99% of patients. Conclusion: We described a new, safe, simple, and rapid approach for bilateral inguinal hernia repair in female pediatric population. A single transverse suprapubic skin incision was adequate for exposing both inguinal regions with excellent postoperative results.
  1 6,773 259
Government initiatives for child health care and the role of pediatric surgeons
Nirmal Chandra Bhattacharyya
October-December 2015, 20(4):163-164
DOI:10.4103/0971-9261.164238  PMID:26628805
  - 3,955 143
Bilateral Wilms' tumors in an infant with Denys-Drash syndrome and rarely seen truncation mutation in the WT1 gene-exon 6
Jayesh Modi, Pranjal Modi, Bipinchandra Pal, Suresh Kumar
October-December 2015, 20(4):197-198
DOI:10.4103/0971-9261.154641  PMID:26628814
  - 4,780 89
Congenital anterior urethral diverticulum: A case report
Manoj Saha
October-December 2015, 20(4):198-199
DOI:10.4103/0971-9261.154642  PMID:26628815
  - 3,594 90
Internal hernia as a cause of bowel strangulation in pediatric age group
Sriharsha Bokka, Madhusoodan Gupta, Fayazuddin Md, Srikant Sharma, Manoj Kumar Mohanty
October-December 2015, 20(4):199-200
DOI:10.4103/0971-9261.154645  PMID:26628816
  - 3,442 101
Posterior ectopic anus: Myth or reality?
Anand Pandey, Shailendra Pal Singh, Vipin Gupta, Rajesh Verma
October-December 2015, 20(4):200-201
DOI:10.4103/0971-9261.154658  PMID:26628817
  - 3,541 111
Use of 'Romodrain' for intercostal drainage in infants
Dinesh Haribhau Kittur, Aditya Joshi
October-December 2015, 20(4):201-202
DOI:10.4103/0971-9261.154668  PMID:26628818
  - 3,213 67
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  2005 - Journal of Indian Association of Pediatric Surgeons | Published by Wolters Kluwer - Medknow 

Online since 1st May '05